ycsE [2017-8-11 16:0:3]

5'-nucleotidase, dephosphorylation of the riboflavin precursor, 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate

locus: BSU04040

pI: 4.49

mw: 27.92 kDa

protein length: 249 aa

gene length: 747 bp

function: dephosphorylation of the riboflavin precursor, 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate

product: 5'-nucleotidase

essential: no

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.2|Biosynthesis/ acquisition of riboflavin/ FAD]

Gene

Coordinates: 456,068 → 456,817

The protein

Catalyzed reaction/ biological activity

• dephosphorylation of the riboflavin precursor, 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate [Pubmed|26316208]

Protein family

• Cof family (according to Swiss-Prot)
• [SW|HAD superfamily] [Pubmed|26316208]

Structure

• [PDB|1NRW] ([protein|AF9523D3AA3C032B70175BCFFED34E9A42ED01AF|PhoC], 31% identity)

Expression and Regulation

Operons

• genes: [gene|D8AC0ECC57C6113D0CCA36FC38395EECBD00FF50|ycsE]
  description: [Pubmed|22383849]

Biological materials

Mutant

• MGNA-C071 (ycsE::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2069 NBRP B. subtilis, Japan]

References

• 16990279,27784292,26316208,22383849,25848029